Anthracene, a well-known DNA intercalator has interesting features which makes it attractive for DNA cross-linking study. It has large binding constant with DNA bases and can be sensitized by DNA. In addition, anthryl chromophore is photo chemically reactive and has large singlet excited state energy, which is good for initiating photochemical reaction. We designed and synthesized several anthracene-based analogues to explore the potential of cross-linking upon photo irradiation. We found that the anthracene analogues highly efficiently induced DNA interstrand cross-link (ICL) formation with fast cross-linking reaction rate. This represents a novel example of photoinduced DNA ICL formation by Anthracene based agents. Subsequently, we will determine the cross-linking site & mechanism of ICL formation as well as modulate the ICL formation efficacy by chemical structure modification.

DNA interstrand cross-link formation by anthrancene anaogues

ACS Spring 2022

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