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May 10, 2018

ESPID 2018

ANTIRETROVIRAL POST-EXPOSURE PROPHYLAXIS (PEP) AFTER SEXUAL EXPOSURE: 7-YEAR REVIEW

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Fonseca, S.;

Melo, A.;

Castro, C.;

Tavares, M.

Abstract

Abstract

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Keywords

Abstract

Background Possible sexual exposure to HIV represents an emergency situation and post-exposure prophylaxis is currently under discussion.28-day course of antiretroviral therapy after sexual exposure is used to prevent HIV infection.The authors proposed to review all cases of sexual exposure over 7 years in a tertiary hospital in northern Portugal where there is an institutional protocol of action, after non-occupational exposure to HIV in children and adolescents, which determines the use of antiretroviral prophylaxis within the first 72 hours after exposure. Case Presentation Summary 50 cases of sexual exposure were identified, with an average of 7 cases/year and a higher number of cases in the last 2 years. 43 cases were female;the cases were aged between 2 and 17 years (median 14). In one case there was sexual contact with an HIV positive source.In all cases HIV serology, prior to prophylaxis, was negative. 31 cases were eligible for HIV infection prophylaxis.The most commonly used combination was Zidovudine+Lamivudine+Tenofovir.From 2015 the protocol indicates as preferred Emtricitabine/Tenofovir+Raltegravir.The prescription is made for a maximum of 5 days, and the physician's telephone contact and scheduled appointment are provided.All cases are followed up by a pediatrician.In 2 cases the antiretroviral therapy was interrupted after confirming the negative source.All the others completed 28 days with good tolerance and were discharged 16 weeks later,with confirmation of negative serology.There was no case of HIV infection. Learning Points/Discussion The prophylaxis schemes used,in constant updating according to scientific evidence,have been shown to be effective and it is important to highlight their early onset and adherence. Despite the dissemination of information on HIV transmission,in our study we identified increasing numbers of sexual exposure with an inherent risk of infection.

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© Copyright 2019 Morressier GmbH.
All rights reserved.