Association of high sensitivity C-reactive protein and insulin resistance with newly diagnosed type 2 diabetic subjects Author Block: Background and aims: High sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, is emerging as an independent risk in subjects with impaired glucose regulation or diabetes. A few prospective studies have shown that increased hsCRP levels are an independent risk factor for future diabetes. However, it remains unclear whether a relationship exists between hsCRP and insulin resistance in newly diagnosed type 2 diabetes (NDD) subjects. Aims: The present study was undertaken to investigate the relationship between hsCRP concentration and insulin resistance in a group of Bangladeshi NDD subject. Materials and methods: Under an observational analytic design a number of 152 NDD [M/F, 88/64; age in years, 46±8; body mass index (BMI) in kg/m2, 25±4; M±SD] subjects and 175 age/-, sex- and BMI- matched healthy control (96/79; 45±8; 24±4) subjects were recruited. NDD was diagnosed as per WHO Study Group criteria following a 2-sample OGTT. Serum glucose was measured by glucose-oxidase method and serum insulin and hsCRP were measured by ELISA techniques. Insulin resistance was measured by homeostasis model assessment (HOMA-IR). Results: Compared to the control subjects, NDD subjects showed significantly higher levels of HOMA-IR (2.40±1.20 vs 0.92±0.32, p<0.001) and hsCRP (5.72±3.50 vs 1.51±0.68 ng/ml, p<0.001). On Pearson’s correlation analysis, HOMA-IR showed significant positive correlation with hsCRP (r=0.280, p=0.006) in NDD subjects. On multiple linear regression analysis, HOMA-IR showed significant positive association with hsCRP (β=0.235, p=0.022) in NDD subjects after adjusting the effects of waist circumference (WC), percent body fat (%BF), and triglyceride (TG) respectively. On binary logistic regression analysis, TG [Odds ratio (OR)=1.012, 95% confidence interval (CI):1.004-1.020, p=0.002], hsCRP (OR=8.760, 95% CI:3.598-21.330, p<0.001) and HOMA-IR (OR=2.171, 95% CI:1.291-3.652, p=0.003) were found to be significant determinants of NDD after adjusting the effects of %BF and WC. Conclusions: Elevated levels of subclinical inflammation seem to have an association with insulin resistance which is one of the pathophysiological determinants of type 2 diabetes.
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