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BK Polyoma Virus in an islet cell transplant cohort

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BTS 2017

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Abstract

Introduction: BK virus nephropathy (BKVN) occurs in approximately 5% of renal transplant recipients (RTRs) and is preceded by BK viremia which occurs in approximately 10-20% of RTRs. It appears to be much less common post non-renal solid organ transplantation, although few robust studies have been performed in this population. There are no published data on BK viremia following islet-cell transplantation (ITx). Methods: We performed cross-sectional testing in our ITx cohort for BK viremia using a PCR assay (Vela Diagnostics-Singapore). Immunosuppression was broadly similar to contemporary RTRs consisting of maintenance therapy using tacrolimus and mycophenolic acid preparations. Induction with alemtuzumab was used allowing for a corticosteroid-free regime. Results: Overall, 19 patients [12 females; mean age 51 years (range 38-73)] had a single test performed. Renal function was stable with an eGFR >60mls/min/1.73m2 in all patients from time of transplantation until BK testing. The mean time of testing was 10.6 months post transplant (range 2-42 months) and all were negative for BK viremia. Discussion: The testing was performed during the ‘at risk’ time for developing BK viremia in RTRs. Recent evidence suggests that BK disease in renal transplantation is primarily due to BK virus transmission by the transplanted organ and may explain the higher incidence in renal transplantation compared with other solid organ or cellular transplants. Our findings suggest that BK virus infection is not common post ITx. However, as we only tested for BK viremia once and at varying time points in each patient. We plan to perform prospective testing at multiple time points which will provide a more robust reflection of the risk of BK virus infection post ITx.

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© Copyright 2019 Morressier GmbH.
All rights reserved.