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Breast cancer, primary peritoneal malignant mixed mullerian tumor and fallopian tube carcinoma: incidental concomitant malignancies or evidence for a new genetic cancer predisposition syndrome?

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ESGO State of the Art 2018 Conference

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Abstract

This a case report on a 72 year old postmenopausal G4P4(4-0-0-4), known case of stage I breast cancer, s/p modified radical mastectomy, maintained on Anastrozole, with no history of chemotherapy or radiotherapy. She has a family history of breast, cervical and kidney cancer. One year later she was diagnosed with synchronous primary peritoneal malignant mixed mullerian tumor (MMMT) and high grade serous fallopian tube carcinoma. While her BRCA status is unknown, recent studies have suggested the existence of another genetic cancer predisposition syndrome linking breast cancer and MMMT. While breast cancer generally has a good prognosis when managed early, MMMT is a high grade tumor with a poor prognosis. Because of this, discovery of such a hereditary link between breast cancer and MMMT impacts not only individuals but entire families as well. This link has been previously proposed but largely ignored. This case provides further support to this theorized gene.

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© Copyright 2020 Morressier GmbH.
All rights reserved.