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Characterization and degradation analyses of PLGA+HA &#946+TCP scaffolds incorporating simvastatin for bone regeneration


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Scaffolds for bone regeneration are beneficial since it has osteoconductive properties. Adding osteoinductive factors to scaffolds might improve the clinical applicability of the biomaterial. Thus, the aim of this study was to synthesize, characterize, and evaluate the degradation of PLGA+HA/βTCP scaffolds incorporating simvastatin to verify if this association could be promising for future clinic application to promote bone regeneration. The samples were obtained by the solvent evaporation technique. After complete dissolution of the polymer in chloroform, sucrose and biphasic ceramic particles (HA (70%) and β-TCP (30%)) were added in a ratio of 1:1 polymer and ceramic. After evaporation of the solvent, sucrose was removed using polyvinyl alcohol. For the samples with simvastatin, 5% of the medication were diluted in chloroform, to which sucrose, HA and β-TCP were added to the diluted polymer. Samples were synthesized in a disc-shape measuring 6 mm x 1 mm and sterilized by gamma radiation. For degradation, the samples were immersed in PBS at 37 °C under constant stirring for 7, 14, 21, and 28 days. Non-degraded samples were taken as reference. Mass variation, scanning electron microscopy and porosity analysis were performed. Additionally, wettability test was conducted. No mass variation was found between scaffolds with and without simvastatin, but scaffolds free of simvastatin increased the mass after 21 and 28 days (Figure 1). Porosity did not vary between groups, except for day 21 (Figure 1). Microscopic images revealed the presence of macro, meso and micropores in the polymer structure, where particles of HA and βTCP were well inserted and dispersed (Figure 2). Scaffolds incorporating simvastatin were more hydrophilic. Scaffolds of PLGA+HA/βTCP with 5% simvastatin presented good properties over a period of 28 days, suggesting to be a promising biomaterial for regeneration of bone.


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All rights reserved.