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May 15, 2019

ESOC-2019

THE CHRONIC POST-STROKE APHASIA SEVERITY: MAGNETIC RESONANSE IMAGING (MRI) STUDY

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stroke

aphasia

speech test

cortex thickness

magnetic resonanse imaging

Abstract

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33

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Abstract

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Keywords

stroke

aphasia

speech test

cortex thickness

magnetic resonanse imaging

Abstract

Aphasia is one of the most frequent post-stroke complications, and at acute stage of stroke the aphasia severity directly depends on a volume of the lesion and it`s localization. However at subactue and chronic stage this correlation between the severity of aphasia and brain lesion become vague. It is also unclear how changes in the cortex thickness can be associated with the severity of speech disorders especially at the chronic post-stroke stage. In order to address these questions we studied a relationship between speech impairment and lesion volume and localization in 15 patients with fluent aphasia in 3 to 24 months after the left hemisphere stroke affected the temporal cortex. Lesion patterns and cortex thickness were determined by magnetic resonance imaging (MRI). The lesion volume negatively but insignificantly correlated with scores of the speech assessment test in aphasia. Only multi-regression analysis revealed significant dependence of speech test scores on two covariates: the lesion volume and difference between temporal cortex thickness in contralesional and ipsilesional hemispheres. The thickness of the temporal lobe cortex in the left hemisphere was significantly less than in the contralateral hemisphere. Additionally, the lesion overlap with language-specific Brodmann areas in the temporal and frontal lobes caused greater severity of aphasia. Our results provide further evidence that at chronic stage not only lesion size but also altered thickness of temporal cortex in both hemispheres influence the speech function in fluent aphasia.

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© Copyright 2019 Morressier GmbH.
All rights reserved.