Jong Sup Park
and 1 other(s)
Aims : Chlamydia trachomatis causing chronic inflammatory diseases has investigated as possible human papillomavirus (HPV) cofactor in cervical cancer. The aim of this study is to evaluate that clearance of HPV in young women with conization was related with Chlamydia trachomatis, Ureaplasma and Mycoplasma. Here, we evaluated the clearance of HPV after conization and identified other co-factors including Chlamydia. Methods : This study was conducted on 70 patients who received conization due to CIN-2,3 and CIS at the St Paul’s Hospital of the Catholic University of Korea from Jul, 2014 until Dec, 2016. Among them, we evaluated the women under 40 years old. They all were positive for high risk HPV at initial visit. Patients were followed in 4-6 month interval with Pap smear and Anyplex TM Real time PCR HPV 28 detection method which detect 19 high-risk HPV genotype , 9 low-risk genotypes. Results : The median age of 22 patients was 30 years. Single and multiple HPV detection was 9 (40.9%) and 13 (59.1%). Of the women received conization, median clearance time of those multiple type HPV was 27 month and that was longer than single type HPV( 22 month, P>0.05) . The median clearance of women infected with Chlamydia, Mycoplasma or Ureaplasma was 27 months and that was longer than other women without Chlamydia, Mycoplasma, or ureaplasma(16 month, P>0.05). Conclusions: : In a follow-up after conization, women with Chlamydia, Ureaplasma, Mycoplasma showed relatively long time persistence. The relation between HPV and Chlamydia will require follow-up epidemiological studies.
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