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Collagen quality as a major factor of bone quality influences the outcome of bone transplantation in vivo


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Background: Bone transplantation is occasionally required prior to implant installation. Since Autografting is thought to be a gold standard for bone augmentation, a proper understanding of the paradigms that affect the outcome of bone transplantation is important for better prognosis. It is believed that bone components other than Bone Mineral Density are also very important determinants of bone quality and one of those is collagen. The influence of collagen quality that possibly affects the outcome of bone grafting is still unknown. Aim and hypothesis: To understand the influences of collagen quality of bone on the prognosis of bone transplantation, we investigated the fate of transplanted bone and adjacent tissues at the recipient site along with the healing of the donor site. Methods and Materials Wister male Rats (n=48) 4 weeks old were divided into test group (n=24) and control group (n=24). 0.2% Beta- Aminoproperionitrile (BAPN) was dissolved in test group water for 4 weeks. Control & Test groups were subdivided equally in to 2 groups; Donor Group (DG) and Recipient Group (RG). The subdivision was made to resemble bone grafting/transplantation settings. Two 5mm diameter calvarial bone chips were harvested from DG and grafted on RG. At 1, 2 and 4 weeks after the surgery, rats were sacrificed and the specimens were prepared from retrieved calvaria for decalcified histological sections. The sections were prepared for observation under light microscopy and histomorphometry. Results: In test group of RG subdivision, bridging rates between transplanted bone chips and recipient surface were higher in the BAPN group compared to control at all time points. Regarding the tissue changes in the calvarial defects of DG subdivision, BAPN group showed faster tissue formation, and gap closure compared to control group. Conclusions and Clinical Implications: A low quality bone grafts could be selected for bone augmentation clinically. In addition, the low collagen quality bone might accelerate bone formation in vivo. However, the maintenance of these formed bones adjacent to such transplants is important and the long term outcome should be studied. The finding reflects the necessity to develop new clinical parameters and methods for comprehensive pre-operative assessment involving the collagen quality.


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© Copyright 2020 Morressier GmbH.
All rights reserved.