Introduction: Burns are the most common skin lesion; they generate a local or systemic inflammatory response according to their depth and/or their burned body surface, burning agent, age and/or comorbidities1; causing an increase in body temperature within the first 24 to 48 hours2.
The burned population with hypothermia3-4, despite physical control before or during their hospital stay, is related to their burn body surface5-6 or alterations in the balance of gain and loss of heat2. It has been observed that patients with hypothermia are associated with increased morbidity and mortality7-11 and no levels of proinflammatory and anti-inflammatory cytokines are known in hypothermic burned patients and their possible relationship.
Methods: Study authorized by the research committee of the INRLGII in April 2014 and has informed consent for its execution.
Prospective study from April 2014 to December 2015, to determine the concentration of cytokines in a group of burned patients admitted to a Center for Specialized Care for Burn with hypothermia. Inclusion criteria: 15% to 60% of TBSA, gender indistinct, zero to 75 years old; hypothermia (temperature ≤ 36.5 degrees) during admission or hospital stay. Exclusion: septic patients.
Determination of serum cytokines was performed in each patient, from the serum frozen at one time by a single operator, by quantitative immunoassay method for IL-6, IL-10, IL-2, INF-Ɣ, IL1-α and TNF. Statistical analysis was performed using descriptive statistics analysis (ANOVA) and Spearman correlation.
Results: A group of 10/18 patients (n = 10) were studied; gender distribution was 40% (n = 4) for females and 60% (n = 6) for the male. Age range was 1-60 years, mean 27 years; 30% of the population was pediatric population ≤ 18 years; and 70% adult population. 70% burn direct fire and 30% scald. TBSA between 15 to 60% with an average of 36.3%. Nine patients survived (90%), one patient died (10%) during the study period. Temperatures range during their hospital stay was 33 to 38.9°C, with an average of 36.03°C. ANOVA analysis significance of p ≤ 0.001.
Spearman correlation: gender relate to the agent that burns the skin; day taken with levels of IL-10; IL-10 with IL-2 and IL-6; IL-6 with INF-ɣ and IL-2 with INF-ɣ in the study two-tailed p≤ significance of p ≤ 0.5 and 0.1.
The deceased patient showed higher levels of IL-6 and IL-10 compared to the rest of the population, as well as lower levels of temperature as the rest of the population; Burn extension of 20%*.
Conclusions: Interleukins levels are different in the states of hypothermia in the burned patients.
Applicability of Research to Practice: Keep warm environments for the care of burned patients.

Correlation of hypothermia and cytokines in burned patients