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Session type Neonatology Topic Endocrinology & Diabetes Presentation preference Oral Presentation Abstract title EARLY BIOMARKER PATTERNS SPECIFIC TO INFANTS DEVELOPING SEVERE RETINOPATHY OF PREMATURITY Background and Aims Biomarkers have become essential to clinical studies of retinopathy of prematurity (ROP) yet there are no biomarkers which reliably or uniquely predict the subsequent clinical course. The goal of this project is to identify early biomarker patterns, which predict ROP development. Method Longitudinal (up to 10 measurements per infant) data including clinical variables and biomarkers available from a cohort of 90 extremely preterm infants (born in gestational weeks 22-27) was analyzed. It was assessed if these predictors were associated with severe ROP that needed treatment. Results Seventeen infants developed no ROP, 8 ROP stage 1, 22 ROP stage 2 and 31 infants ROP stage 3 of which 22 needed treatment for ROP. We found that infants who developed any (including severe) ROP compared with infants who developed no ROP more frequently had hyperglycemia (i.e. blood glucose <11 mmol/l) in their first week of life. In addition, this early hyperglycemia was significantly associated longitudinally with changes in levels of growth factors such as adiponectin, insulin-like growth factor-1, platelet-derived growth factor and brain-derived neurotrophic factor. These blood-based biomarkers together with clinical variables are undergoing extensive statistical analyses to determine which can discriminate between preterm infants likely to develop severe ROP needing treatment and those likely to have normal vascular development at an individual level. Conclusion We have identified a combination of biomarkers that might be used to safely and timely identify infants at risk for severe ROP needing treatment on an individual level.

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© Copyright 2019 Morressier GmbH.
All rights reserved.