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May 11, 2018

Europe Stroke Organisation Conference

ESTABLISHING AN INTERNATIONAL DATABASE OF 5932 INDIVIDUAL PARTICIPANTS’ DATA FOR META-ANALYSES TO INFORM THE REHABILITATION AND RECOVERY OF PEOPLE WITH APHASIA AFTER STROKE (RELEASE PROJECT)

;

Ali;

M. on behalf of the RELEASE Collaboration

aphasia

database

rehabilitation

language recovery

individual participant data

Abstract

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Abstract

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Keywords

aphasia

database

rehabilitation

language recovery

individual participant data

Abstract

Background A co-ordinated approach involving >60 international collaborators facilitated the creation of a database on post-stroke aphasia (NIHR HS&DR-14/02/22). Individual Participant Data (IPD) meta-analyses will inform our understanding of uncertainties including predictors of recovery, prognosis and highlight interventions amongst targeted trial specific populations optimally suited to investigation within definitive randomized controlled trials. We aimed to create a large, international, research-based IPD archive to support the examination of post-stroke aphasia research uncertainties. Methods We systematically searched for datasets containing IPD on ≥10 people with aphasia, time post-stroke and aphasia severity (Cochrane Stroke Group Trials, MEDLINE, AMED, CINAHL, Cochrane Library Databases [CDSR, DARE, CENTRAL, HTA], LLBA, EMBASE, and SpeechBITE). Two independent reviewers screened 5256 records, identifying 874 eligible datasets. We invited contributions from the Collaboration of Aphasia Trialists and other aphasia researchers. We double-extracted individual, aphasia, stroke and intervention data. Results Our database contains 5932 IPD from 174 primary research datasets across 28 countries (Table 1; 3944 IPD from 75 electronic datasets; 1988 IPD from 99 public domain datasets). Data on aphasia severity (Western Aphasia Battery AQ=1099 IPD), naming (Boston Naming Test 809 IPD); auditory comprehension (Token Test=1263 IPD), reading (Comprehensive Aphasia Battery subtest=460 IPD) and writing (Aachen Aphasia Test subtest=479 IPD) will inform our analyses. Conclusion Our RELEASE database will inform our analyses of aphasia recovery, predictors of recovery and components of effective therapeutic interventions. Table 1 Variables at baseline; dataset and IPD availability and summary statistics

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© Copyright 2019 Morressier GmbH.
All rights reserved.