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FAST-ACTING INSULIN ASPART IMPROVES GLYCEMIC VARIABILITY IN SUBJECTS WITH DIABETES TYTPE 1 TREATED WITH INSULIN PUMPS

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Abstract

Background and Aims. Fast-acting insulin aspart (FIASP®) administered by continuous subcutaneous insulin infusion (CSII) shows, in comparison to conventional insulin aspart (IAsp), a faster on and faster off action, and more than double insulin action during the first 30’ of infusion. However, there are no studies aimed to compare the effectiveness of FIASP® and IAsp in subjects treated with CSII in a real life-setting.Materials and Methods. We studied 17 adult subjects (13 males; age = 43.1 years ± 10.4 DS; HbA1c at baseline = 6.98% ± 1.13 DS) with type 1 diabetes, treated with CSII by Medtronic Minimed ® 640G system. Main outcomes were: difference of mean and coefficient of variation (CV) of glucose measurements (GM) obtained during 2 weeks of continuous glucose monitoring (CGM), respectively 2 weeks before and after switch from IAsp to FIASP®; the number of drop-outs.Results. After switch the mean of GM was not different (153,4 mg% ± 20.7 DS vs 154,3 ± 17,8 DS; n.s.; Figure 1), but CV of GM decreased significantly (32.7% ± 4.9% DS vs 28,6% ± 3.8% DS; P < 0.05; Figure 2). We recorded one drop-out for problems in the infusion site and 3 drop-outs in subjects who needed to increase basal insulin infusion rate more than 2 times with FIASP®.Discussion and Conclusions. The pharmacokinetic properties of FIASP® may be advantageous for subjects using CSII because it decreases glycemic variability without increasing mean GM, but we need to better understand how to optimize the insulin infusion rates.

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© Copyright 2019 Morressier GmbH.
All rights reserved.