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GLYCEMIC CONTROL AND HYPOGLYCEMIA IN PATIENTS TREATED WITH INSULIN PUMP THERAPY: OBSERVATIONAL STUDY

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Abstract

Diabetes mellitus (DM) is a disease with a high prevalence worldwide. It has been associated with an important morbidity and mortality obtained from complications and sometimes, from treatment. The insulin pump therapy (IPT) is one of the options used to control the disease and reduce one of the most frequent complications acquired from treatment, the hypoglycemia; which also has a great impact on life quality and clinical status of the patients. Materials and methods: A retrospective and descriptive study was performed including patients treated and followed by the endocrinology department from a highly complex hospital in Cali, Colombia, between 2012 and 2017. Patients were in IPT and continuous glucose monitoring (CGM): MiniMed® Veo™ Insulin Pump - Paradigm® REAL-Time™ sensor (Medtronic®) and MiniMed® 640G insulin pump - Enlite® sensor (Medtronic®); there was evaluated the presence of hypoglycemia and associated factors with its development. Results: 51 patients were included. The main indication for insulin pump use was the presence of hypoglycemia and inappropriate metabolic control. The initiation of IPT was related with a decrease in glycosylated hemoglobin (HbA1c) (Fig1), severe hypoglycemic events and hospitalization due to hypoglycemia. The linked risk factors with clinically significant hypoglycemia were male gender and standard deviation. A diminished glomerular filtration rate (GFR) (<60 mL/min/1.73 m2) was correlated with higher risk of severe hypoglycemia. Conclusion: The IPT with CGM is a useful strategy in the management of patients with DM, it is associated with a reduction of hypoglycemia events and hospitalization for hypoglycemia.

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© Copyright 2020 Morressier GmbH.
All rights reserved.