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GRANULOSA OVARIAN TUMOR RARE JEVENILE AND ADULT CHARACTERISTIC ANATOMO CLINICAL AND THERAPEUTIC STUDY RETOSPECTIVE EXPERIMENT OF ALGIERS

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ESGO State of the Art 2018 Conference

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Abstract

: F.HADJARAB1, C.CHEKMAN2 ,A.BOUFENNARA3 A.TAIB1I, K.BOUZID1 1 Department of medical oncology, Center Pierre and Marie curie Algiers Algeria 2 SURGERY 3 HISTOLOGY Introduction : The tumors of granulosa are rare ovarian cancer with rather Slow evolution if one them compared to Germinal or epithelial tumors of the ovary, they account for 0.6% to 3% of the whole of the tumors of the ovary and 5% of the malignant tumors of this one . Their diagnosis is anatomopathologic resting primarily on data morphologics. Two types are distinguished: the adult type (TGA) which is most frequent, and type (TGJ), this last is characterized by an age from which has occurred relatively young person, a morphological aspect different involving histological signs from malignity more marked and a higher risk of repetition. These tumours have a profile clinical, histological and evolutionary particular. a retrospective study of 24 files carrying the diagnosis of tumour granulosa (TG) which collaged during the 10 years period, energy fromJ anuary 2006 with December 2016 parameters studied in these patients: (the age ofthe diagnosis, the circumstance of discovery,assessment initial (diagnosis and assessment of extension), the stage of the FIGO, it surgical epic,chemotherapy used and the therapeutic answer,total survival) 23 patients were standard adult Granulosa (TGA),only one waits were standard Granulosa jévunile (TGJ), the âge of patient at the time of the diagnosis varied from 22 to 72 year s, the hormonal statute was variable and the circumstances of discoveries were dominated by pains abdomino-pelvic dans= 15 case (62%), métrorragies in =4case , amenorrhoea in =4 case,, pelvicmass in =6 case ,), the pelvic echoraphy was practised at all our patients the tumour was solidokystic at 60% of our patients, cystic in 5%of and solid in 35% cases. Tumours werebulky with a size varies from 7 to 27 cm, with an average of 10 cm. average of 10 cm. Stages 19 stage I , 1 stage II, 3 stage III, 1stage IV, All the patients profited from a surgical, radical in 18 cases (hysterectomy with annexectomy bilateral), in 6 cases unilateral annexectomy (young woman) 6 patients have receipt of auxiliary chemotherapy stage I E tIIwith two types of protocols: cisplatin, vinblastine,bleomycin), And 4 with the protocol: paclitaxel, carboplatin thepatients at the stages III profited from an auxiliarychemotherapy néo with the protocol cisplatine,bléomycine, vinblastine followed by surgery with astabilization of the lesions, two patients repeated,the youthful form presented a local repetition one year after head end ,which died by evolutionary ,continuation of the disease The other presented lesions in the form of carcinogen peritoneal and having received chemotherapy type paclitaxel carboplatine,presented a complete good answer , Median of survival =26month Tumors of ovarian are rare ,adult forms forms are slow –moving ,often diagnosed at an early stage ,treatment relies on surgery ,we note in our series that age , stage at diagnosis was correlate with that of literature

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