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INTENSIVE INSULIN THERAPY WITH CONTINUOUS SUBCUTANEOUS INSULIN INFUSION

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Abstract

Objective: To compare intensive insulin therapy through continuous subcutaneous insulin infusion (CSII) and multiple daily insulin injections (MIDI) regarding glycemic control, microalbuminuria, lipid profile, body mass index and frequency of adverse events. Material and Methods: Retrospective observational study involving 59 patients with type 1 diabetes followed at endocrinology clinic of the São João Hospital Center that performed intensive insulin therapy through CSII for more than 6 years, having previously used the MIDI for a period of more than 6 months. Data was collected from the clinical process comparing the period of MIDI and after 2, 4 and 6 years after CSII. Results: 59 patients with a mean age of 41 ± 10 years, diagnosed with type 1 diabetes and with an average disease duration of disease of 17 ± 9 years were evaluated. The HbA1c values ​​were significantly lower in the three CSII periods compared to the MIDI period. The parameters of the lipid profile, ISF and I:CH ratio did not show statistically significant differences in any of the periods.The median values ​​of microalbuminuria of the MIDI period was identical to the period of CSII. Regarding body mass index, a statistically significant increase was found 6 years after start of CSII. The frequency of adverse events associated with CSII therapy was reduced. Conclusion: The change from the MIDI to CSII strategy allowed a better glycemic control during the first 6 years, with no change in the lipid profile or high frequency of adverse events.

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© Copyright 2020 Morressier GmbH.
All rights reserved.