Juvenile SLE with lupus Anticoagulant and hypoprothrominemia syndrome
Mohammed Olfat, MD1. Ahmed Tarawah, MD2. Doaa Mohammed3. Meyasser Olfat4.
• ¹ Division of Rheumatology, Maternity and Children Hospital
• 2 Division of Hematology, Maternity and Children Hospital
• 3 Division of paediatrics, Maternity and Children Hospital
• 4 Medical school, Taibah University
• Corresponding Author:
• Mohammed Olfat, MD
• Division of Rheumatology
• Maternity and Children Hospital
• Prince Abdul Majeed Road
• Medina, Saudi Arabia
• Phone: +966-5-04356467
• Fax: +966-14-8640915
• e-mail: firstname.lastname@example.org
Lupus anticoagulant and hypoprothrombinemia syndrome (LAC–HPS) is a rare clinical entity that can occur in association with juvenile SLE. We described a girl with systemic lupus erythematosus who developed hemorrhagic tendencies as a consequence of a clotting factor II (prothrombin) deficiency. She responded rapidly to treatment with corticosteroids and the coadministration of vitamin K and fresh frozen plasma. The addition of cellcept has enabled the control of disease manifestations and the reduction in steroid doses.