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Oct 10, 2018

7th Congress of the European Academy of Paediatric Societies

KAWASAKI DISEASE IN INFANTS LESS THAN ONE YEAR OF AGE: AN ITALIAN COHORT

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kawasaki disease

infancy

coronary disease

Abstract

Abstract

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Keywords

kawasaki disease

infancy

coronary disease

Abstract

Background and Aims Kawasaki disease (KD) in infancy is often characterized by incomplete forms. There are few data on KD in children below 12 months especially in Caucasians. This study aims to analyze clinical and laboratory features of KD among an Italian cohort of infants below 12 months. Methods Retrospective chart review of children diagnosed with KD between January 2008 and December 2017. Data were analyzed by Epi Info Statistical Software version 7.1.5.2. Results Of 113 patients with KD, 32 (28,3%) were less than 1 year (M:F= 20:12). The median age was 5,7 ± 2,7 months. 19 patients (59,4%) were less than 6 months. Mucosal changes were present in 13 patients (40,6%); extremity changes in 18 (56,2 %); rash in 25 (78,1 %); conjunctival injection in 26 (81,2%) and cervical lymphadenopathy in 7 (21,8 %). 22 patients (68,7%) had incomplete KD. Heart involvement was present in 19 (59,4%) patients of whom 13 (59,0%) had incomplete form. The mean time for diagnosis was 7 days (range 3-22) and it was longer in the incomplete KD (7,6 VS 5,8). ESR, PCR and platelets values were all higher in complete KD than in incomplete forms, without any significant difference between the two groups. All patients received IVIG. Conclusion In our cohort incomplete KD was commonly found, resulting in delayed diagnoses. Therefore, infants with incomplete KD have a more severe disease and a greater predilection for cardiac involvement. To our knowledge this is the first study that involves an Italian cohort of patients with KD below 12 months.

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© Copyright 2019 Morressier GmbH.
All rights reserved.