Background & Aim: Stroke can lead to musculoskeletal and respiratory dysfunctions, chronic deconditioning and disability. The aim was to evaluate the association between cardiopulmonary and peripheral muscle function in the acute phase of stroke and severity, dependence degree and functional capacity in long term. Method: Prospective study with 46 patients admitted to the stroke unit. Cardiopulmonary function was assessed by echocardiographic evaluation, respiratory muscle strength (MEP - maximal expiratory pressure) by manovacuometry and handgrip strength in the first 72 hours after stroke. Functional capacity was assessed by mRs, and Barthel's index, and stroke severity by the NIHSS at discharge and 90 days after hospital discharge. Statistical analysis: multiple linear regression to verify the correlation between cardiopulmonary and peripheral muscle function and outcomes adjusted by confounding variables (NIHSS at admission, age and sex). Significance level 5%. Results: MEP showed a negative correlation with increase in NIHSS (β=-0.016, p=0.011) at hospital discharge, handgrip strength on the unaffected side had a correlation with the better functional capacity assessed by mRs (β=-0.034, p=0.049) and Barthel's index (β=0.480, p=0.023) at hospital discharge. The left ventricular mass corrected for body surface area had negative correlation with the increase in mRs (β=-0.010, p=0.027) and NIHSS (β=-0.012, p=0.021), and presented a positive correlation with Barthel's index (β=0.051, p=0.048) 90 days after hospital discharge adjusted for confounding variables. Conclusion: In the acute phase of stroke, the worst cardiopulmonary and peripheral functions are related to the worst functional outcome 90 days after hospital discharge.
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