Dendrimers—highly branched macromolecules—present an attractive scaffold to support catalytic moieties. Polyamidoamine (PAMAM) dendrimers were terminally functionalized with the MacMillan group's (<i>2S,5S</i>)-5-benzyl-2-tert-butyl-3-methyl-imidazolidin-4-one catalyst. Functionalized PAMAM dendrimers were characterized by NMR, MALDI-TOF MS, and XPS analysis.  These PAMAM dendrimers (generations 2, 3 and 4) were screened under MacMillan's asymmetric Diels-Alder reaction conditions.

MacMillan-type Diels-Alder reactions using PAMAM bound imidazolidinone organocatalysts

255th National Meeting (2018)

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