Imene Ben Romdhane
Objectives: We propose to study the developmental psychopathology model of the transmission of risk from mothers with schizophrenia(SCZ) to their children. Background: Children of mothers with SCZ are at risk for psychiatric disorders.The intergenerational transmission include both genetic and environmental factors. Materials and Methods: We report the case of two patients:a mother diagnosed with SCZ and her daughter with schizoaffective disorder(SZA). A review of the literature was also conducted using the databases“PubMed” and“ScienceDirect” and the keywords:schizophrenia,mother,transmission,psychopathology. Results and Conclusion: Mrs L.O is 61years old,married,mother of 3children. She has been suffering from SCZ since the age of27. At the age of31, she was pregnant with her oldest daughter A.O. In the post partum period, she was admitted to a psychiatric service for relapse of her illness. She was treated by atypical antipsychotics. Mrs L.O didn’t come to follow up visits from1988 to2007. In2007, 19years after being exposed to maternal schizophrenic symptoms,Mrs A.O was hospitalized in our service. The diagnosis of SZA seemed the most suitable. Studies have shown that mental illness in children from mothers with SCZ may result not only from a shared genetic risk, but also from developmental factors interacting with environmental stressors.The case of our study highlights that parenting behaviour in mothers withSCZ may lead to social and cognitive deficits in children,which convey mental illness. Conclusion:Psychopathology of transmission risk from mothers withSCZ to children is multifactorial. The maternal treatment of symptoms and a social support of these mothers seem to be crucial to reduce the effect of maladaptive maternal behaviours and moderate effect of illness severity on offspring.
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