Title: Neutrophil-Lymphocyte Ratio and Microvascular complications in Pakistani subjects with type 2 diabetes Author list: Anum butt,Asher Fawwad, Iftikhar Ahmed Siddiqui ,Maria Khalid,Rubina Sabir,Abdul Basit. Abstract: Background: The purpose of present study is to find relation between diabetic microvascular complications and Neutrophil-Lymphocyte ratio (NLR) in subjects having type 2 diabetes. Methodology: It was a retrospective study based on the hospital data records from January 2005 to May 2016 at Baqai Institute (BIDE). The eligible criteria were subjects having type 2 diabetes with their latest complete blood count (CBC) and subjects with conditions such as chronic inflammation,cancer,heart failure and ESRD were included in noneligible criteria. Subjects divided into two groups; one with any microvascular complication and other with no microvascular complication.Body mass index (BMI) anthropometric measurements, blood pressurewere measured. Results: Out of 5620 type 2 diabetic subjects, 3202 (57%) were male and (2418) 43% were female. 3374 diabetic subjects had one or more microvascular complication and 2246 had no microvascular complication. Neutrophil to lymphocyte ratio (NLR) was found to be 1.14 times higherin diabetic subjects having at least one microvascular complications as compared to diabetic subjects without any complication (p<0.0001). Factors likely associated with microvascular complications were high level of Neutrophil to lymphocyte ratio, HbA1c, Serum creatinine, Systolic blood pressure and longer duration of diabetes. Conclusion: According to the results, it is concluded that NLR is an efficient, cheaper and readily available marker of inflammation and itis knownas an important predictor for the existence of microvascular complications for patient of type 2 diabetes.
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