Introduction: Based on the experience gained with oral rehabilitation in patients with cancer submitted to therapies with antiresorptive and/or antiangiogenic agents combined with scientific evidence in databases, this case series aims to describe oral rehabilitation recommended by the Clinical Research Center at Bauru School of Dentistry of the University of São Paulo. We described specific management of the patient during the rehabilitation process and the choice of the most suitable dental prosthesis.
Methods: Methods were investigated in scientific literature for rehabilitation to minimize the chances of MRONJ that may be caused by trauma related to these prostheses, as well as the management of these patients during the rehabilitation clinical stages.
Results: Eight patients with history of cancer and submitted to an antineoplastic therapy which may cause MRONJ were treated with dental prostheses according to their specific needs and limitations. No patient was diagnosed with post rehabilitation MRONJ. Follow-up period ranged from 3 to 41 months.
Conclusions: Dental rehabilitation considering systemic limitations imposed by MRONJ, excluding clinical stages that may bring harm to both soft tissues and bone like extended surgeries, implants and conventional removable prostheses seems to be possible and favorable. However, it is cleared the need for more solid evidence described in literature.