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Apr 25, 2020

ACS Spring 2020 National Meeting & Expo

Organic nanoprobes for photoacoustic imaging in biomedical applications

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Abstract

Photoacoustic imaging techniques, which combine the high sensitivity and contrast of optical imaging with good tissue penetration ability of ultrasound, have shown great potential in versatile biomedical applications. To acquire desired functional information from photoacoustic imaging, researchers have been dedicated to exploring novel contrast agents using different materials. It is generally considered that the large absorption coefficient at long wavelength and high nonradiative nature of contrast agents are two dominant factors to yield strong photoacoustic signals.1 Recently, we have designed a series of semiconducting polymers with large absorption coefficient in the near-infrared (NIR) region. In addition, we have demonstrated their exciting performance in stem cell tracking, tumor detection and treatment, and precise nanoparticle delivery. For instance, the photoacoustic cell trackers allow researchers to monitor the delivery and engraftment of stem cell-derived cardiomyocytes in beating mouse hearts with high resolution.2,3 On the other hand, we also discovered that NIR light can facilitate the precise and efficient delivery of photoacoustic nanoparticles to specific tumor tissues via a transient vascular barrier opening process, which opening a new door in nanoparticle-based delivery system. In this talk, the speaker will introduce our recent progresses in exploration of advanced photoacoustic nanoprobes and their biomedical application.<br/><br/>

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© Copyright 2019 Morressier GmbH.
All rights reserved.