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Feb 14, 2019

12th International Conference on Advanced Technologies & Treatments for Diabetes

SOME PARAMETERS OF CARBONYL AND OXIDATIVE STRESS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND MACROANGIOPATHY OF THE LOWER EXTREMITIES

carbonyl stress

oxidative stress

type 2 diabetes mellitus

macroangiopathy of the lower extremities

Abstract

Abstract

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Keywords

carbonyl stress

oxidative stress

type 2 diabetes mellitus

macroangiopathy of the lower extremities

Abstract

Background and Aims The most dangerous consequences global epidemy of diabetes mellitus are its systemic vascular complications - nephropathy, retinopathy, vascular disease of the heart, brain, peripheral vessels of the lower extremities. These complications are the main cause disability and mortality of patients with diabetes. Oxidative stress is considered important in the pathogenesis of vascular complications. The aim is to study of carbonyl and oxidative stress some parameters in patients with type 2 diabetes mellitus (T2DM) and macroangiopathy of the lower extremities. Method 40 men with T2DM and macroangiopathy of the lower extremities, 20 men with T2DM without such complications and 30 healthy men (control group) were involved in the study. Methods of high-performance liquid chromatography were used. Results The malonic dialdehyde content in the T2DM group without macroangiopathy was higher than in the control group (by 112%), and in the group with macroangiopathy of the lower extremities there was an increase by 30% in relation to the control and a decrease by 28% in relation to the group without complications. The development of macroangiopathy of the lower extremities in patients with T2DM is accompanied also by an intensification of carbonyl stress (an increase glyoxal (by 11 time) and methylglyoxal levels (by 13 times)) in relation to the control group. Conclusion The obtained results indicated on prevalence of carbonyl and oxidative stress and a decrease in antioxidant factors in patients with type 2 diabetes with macroangiopathy of the lower extremities. The level of some parameters of carbonyl and oxidative stress may be the criteria for the development of vascular complications in patients with type 2 diabetes mellitus and macroangiopathy of the lower extremities.

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© Copyright 2019 Morressier GmbH.
All rights reserved.