Objectives The aim of this study was to present an in-depth analysis of 843 patients with CMT treated at a single-center over the past thirty years. Design Age, date-of-birth-year, gender, medical- and family-history, CMT-types, -numbers, -severity, -region, -symmetry, -patterns using the tooth agenesis code (TAC), and -growth types of all clinically and radiographically diagnosed CMT-patients were collected. Age and occurrence of syndromes were used to divide CMT-patients into non-syndromic patients older than nine years (group1) and syndromic CMT-patients (group2). Groups were compared especially regarding gender and CMT-severity. Results The average CMT-number per patient was 5.5 (group1, n=816, 59.9% female) and 15.1 (group2, n=27, 29.6% female). There were significant less male (40.1% vs. 70.4%, respectively; P=0.002) as well as significantly less male oligodontia (44.8% vs. 73.9%, respectively; P=0.009) in group1 than in group2. Group1 resulted in decreased frequency of similar CMT-patterns with severity; the most frequent CMT was the 2nd premolar; there were no significant differences between the right and left side, whereas more CMT affected the maxilla; the majority of patients presented with bilateral-CMT (82.8%); females were more affected by CMT but more males had severer forms; certain single CMT differed by gender, and CMT was related to first-grade-relatives. Conclusion The less severe the CMT-form, the more uniformity between gender regarding CMT-pattern was observed. Gender-specific association regarding CMT-number, severity groups and single CMT were found.
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