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May 13, 2019

ESOC-2019

PLATELET-TO-LYMPHOCYTE RATIO AS A PREDICTIVE INDEX OF NEUROLOGICAL OUTCOMES IN ISCHEMIC STROKE

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glasgow coma scale

stroke infarct

lymphocyte count

platelet count

platelet to lymphocyte ratio

Abstract

Abstract

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Keywords

glasgow coma scale

stroke infarct

lymphocyte count

platelet count

platelet to lymphocyte ratio

Abstract

Background and Aims Stroke is the second leading cause of mortality and the third leading cause of morbidity worldwide. Recently, the platelet-to-lymphocyte ratio (PLR) as a potential marker to determine increased inflammation were found to be an independent predictor of the occurrence of delayed cerebral ischemia. In this study we aimed to evaluate whether the PLR had a prognostic role in stroke patients. Method This study included 144 consecutive patients who were admitted to Sardjito Hospital a teaching hospital of Gadjah Mada University for acute ischemic stroke. Platelet-to-lymphocyte ratio (PLR) were calculated from the platelets and absolute lymphocyte count drawn at admission. Clinical outcomes, including GCS and Barthel Index at hospital discharge were also recorded. Primary end point was GCS at hospital discharge (GCSdis). Results The mean age of 144 patients was 62,2 years and 56,1% were male. The PLR cut-off value of 100, found that PLR >100 associated with worse GCSdis (OR: 1.96 , 95% CI 1.23-2.07). The PLR value above the cut-off value collerate with worse clinical outcome examined by Barthel Index. Receiver operating characteristics (ROC) curve analysis revealed that the PLR 195.0 (AUC: 0.536, sensitivity: 40,9%, specificity: 72,8) may be used to determine worsened GCS due to stroke ischemic. Conclusion High platelet-to-lymphocyte ratio (PLR) was significantly associated with short-term neurological outcome with the advantage of being inexpensive and readily available.

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© Copyright 2019 Morressier GmbH.
All rights reserved.