The prevalence of ADH1B and OPRM1 predisposing alleles for alcohol consumption are increased in the Hungarian psoriasis population

Zita Szentkereszty-Kovács1, Szilvia Fiatal2, Eszter Janka1, Krisztina Herszényi3, Péter Holló3, Andrea Szegedi1,  Éva Remenyik1, Dániel Törőcsik1

1.Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
2.Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary 
3.Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary

The objective of our study was to investigate the association of psoriasis with several established alcohol consumption and dependence related gene variants.  
A population based case-control study including 3743 subjects (776 PsV cases form our psoriasis cohort in Debrecen, Hungary and 2967 controls from the general Hungarian population) was conducted. Genotyping of 23 single nucleotide polymorphisms (SNPs) at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined using Mass Array platform with iPLEX Gold Chemistry (Sequenom). Differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were also implemented. 
The comparison of allele distributions revealed a significantly higher prevalence of the C allele of the rs1229984 polymorphism (ADH1B gene) in the PsV population compared to the general population (94.6% vs. 92.04%, p=0.001, respectively). Furthermore the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation by two-fold (ORadditive=1.99, 95%CI: 1.36-2.91, ORdominant=2.01, 95% CI: 1.35-3.01).
Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population, therefore genetic determinants of health behavior should be accounted in prevention strategies and therapeutical management.