Nanoscale machines that can move autonomously, adapt their response, and deliver cargo on demand with high selectivity, represent one of the ultimate goals for researchers in the field of nano-biotechnology. Inorganic and/or bio-catalytically powered, have been designed to reach that goal,<sup>[1],[2]</sup> including the use of enzymatic reactions to power motion at the micro and nanoscale.<sup>[3] </sup>However, as new systems and structures are developed, there is an increasing need to understand fundamentally the aspects that affect motion output, beyond size, shape, and enzymatic reaction rate. In an effort to expand our knowledge of enzyme-powered systems, we have employed supramolecular assemblies for the dynamic encapsulation of enzymes in a stomatocyte-shaped motor, nanovesicle assembled from amphiphilic block copolymers, facilitating catalyst protection and material exchange asymmetrically. The folding process can be precisely controlled to generate different complex architectures [3] with adjustable openings and selective entrapment.The generation of gradients and motor response in such structure, does not depend only on the reaction rate, but also on the substrate and product interactions with the soft solid interface, and their effect on the particle environment. Applications of these supramolecular motors have also been explored, with a major emphasis in stimuli-responsive motion with multi-enzyme devices, with potential for on-site treatment.

Programming motility of biomimetic systems via enzyme catalysis from fundamentals to applications

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.