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Rational Design of a Stable, Effective, and Sustainable Dexamethasone Delivery Platform on Ti Implant- An Innovative Application of Metal Organic Framework in Bone implants

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EAO-2018

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Abstract

Endowing titanium (Ti) implants long-term and controlled drug delivery capability to promote osseointegration and osteogenesis has become an emerging field. However, most of the currently developed implants are far from satisfactory because of some inherent defects. In this work, we constructed a stable, effective, and sustainable DEX delivery platform on Ti disc by immobilizing DEX@zeolitic imidazolate framework-8 (DEX@ZIF-8) nanoparticles into the micrometer-scale artificial etch pits on Ti substrate using methanol-induced regenerated silk fibroin (SF) membrane encapsulation. In vitro cell culture indicated that the SF-DEX@ZIF-8-Ti had good cytocompatibility with MC3T3-E1 cells. Besides, the cells cultured on the SF-DEX@ZIF-8-Ti demonstrated higher differentiation, calcium deposition, and osteogenic genes expressions than the cells cultured on the SF-ZIF-8-Ti and pristine Ti. DEX was utilized as a drug model and could be replaced by other osteogenic drugs or growth factors. Thus, we believed that our design philosophy could inspire future research work in developing Ti implants.

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Morressier

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Morressier

© Copyright 2020 Morressier GmbH.
All rights reserved.