If nature does not need organic solvents to perform complex chemical reactions, which it efficiently does only in water then why would synthetic chemist choose to use environmentally egregious organic solvents to synthesize compounds of pharmaceutical/agrochemical/material interests? The partial and most arguable answer to this is a need of organic solvent (or so called first approach) to dissolve reactants so that they could react. Certainly, and quite forcefully (by policies), chemical industries are trying a “switch” to use sustainable solvents, ionic liquids, sCO<sub>2</sub>, and in fact, water itself (second approach). However, this approach is mostly limited to academic purpose as there are several limitations when scale goes up. With selected case studies, this presentation will demonstrate that the presence of very small quantities of natural product-based surfactant in water could self-assemble into nano-reactors (nano-micelles) which remarkably increase the reaction rate and selectivity under mild conditions for cross coupling reactions using only <i>ppm</i> Pd-catalysts.

Third or sustainable approach in synthesis of drugs or agrochemicals using cross-coupling reactions

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.