THROMBOLYSIS OVER 80 YEARS IN THE LATER TIME WINDOW. HOSPITAL-BASED STUDY Background and Aims: About 30% of admitted ischemic stroke patients are over 80 years old. Large portion of these elderly patients are possible candidates for intravenous thrombolysis (IVT). However regulations and reccomendations regarding to this population are divergent. Aim of our retrospective study to determine the rate of intracerebral hemorrhage (ICH), symptomatic ICH (SICH), mortality and functional outcome of IVT in patients with acute ischemic stroke (AIS) over 80 years within 3 hours compared to 3-4,5 hours. Method: We analyzed all the AIS patients over 80 years who went through IVT at our hospital between 01/01/2015 and 31/10/2017. NIH Stroke Scale (NIHSS), rate of ICH and SICH, mortality, modified Rankin Scale (mRS) at 3 moths and radiographic description of ICH according to Heidelberg classification were compared between the groups treated within 3 hours and 3-4,5 hours. Results: Majority of ICH were classified as class 1a (33,3%) and class 2 (33,3%) in the early time window and as class 2 (57,1%) in the later time window. Conclusion: AIS patients over 80 years treated with IVT at 3-4,5 hours compared within 3 hours do not differ significantly in the rate of ICH, SICH, mortality and functional independence at 3 months. Elderly patients should not be denied IVT in the later time window solely beause of age.
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