Background and Aims Speedy delivery is a crucial factor in ensuring reperfusion therapy approaches deliver most benefit per unit cost. Systems based approaches in reducing the time to reperfusion are important in the delivery of best patient outcomes and best value care. Using a combination of adaptive collaborative workflow embedded within a knowledge translation framework, Thrombolysis and Endovascular WorkFLOw Network (TEFLON) aims to test a system strategy to better deliver high-value care in reperfusion interventions by reducing treatment delays. Method This is an implementation and knowledge transfer trial of a package intervention aiming to identify and address system of care gaps in acute stroke reperfusion treatment delivery across two Comprehensive Stroke Centres (CSCs) in Sydney, Liverpool and Prince of Wales Hospitals. Following a baseline phase, processes of care are being mapped and measured, clinicians and management stakeholders are being consulted, and a new workflow model of care is being developed - the TEFLON system-based model. We will then conduct a preliminary pre- versus post-implementation controlled trial of the TEFLON model Results The primary outcomes of this initial phase of TEFLON will be improvements in the process of care and in reducing treatment delays – specifically clinically meaningful reductions in door to needle or groin time (DNT/DGT) of 20 minutes. Conclusion If successful, this model will provide improved efficiency in the delivery of reperfusion therapy across two major hospitals in Sydney. This will provide a strong platform for city-wide (Sydney), state-wide (NSW), and potentially national rollout of a system-based reperfusion implementation plan.
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