and 4 other(s)
Background Depression after stroke potentially worsens outcome and affects quality of life. We aimed to investigate the use of antidepressants within first year after ischemic stroke in young patients and assess which characteristics are associated with post-stroke antidepressant (PSAD) use. Materials and methods The Helsinki Young Stoke Registry (HYSR) includes 1008 consecutive patients with first-ever ischemic stroke aged 15–49 years. We obtained data from the nationwide Drug Prescription Register and Care Register for Health Care (prior psychiatric hospitalizations). Filled prescription for antidepressant medication within 1 year from stroke was considered as PSAD use. Multivariable logistic regression analysis allowed assessing baseline factors associated with PSAD use, adjusting for age, sex, and factors with a P<0.1 in univariate comparison. Results A total of 889 patients were included, of which 207 (23%) had PSAD use within 1 year from stroke. Those 77 patients who had use of antidepressants 1 year prior stroke were excluded. Compared to patients without PSAD use, PSAD users were less often blue-collar workers, more often cigarette smokers, they had more often silent infarcts, and more severe strokes. Strokes were also more often large anterior infarcts and caused by large artery atherosclerosis. These patients also more often had a history of psychiatric hospitalization. In multivariable analysis smoking, NIHSS score, large anterior territory strokes, and silent infarcts were associated with PSAD use. Results are shown in Table 1. Conclusions • More severe symptoms, • cigarette smoking, • large anterior strokes, and • silent infarcts were associated with antidepressant use within 1 year after ischemic stroke in young adults.
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