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May 28, 2019

PTCOG58

Verification of pencil beam dose calculation in tissues of a MATLAB-based proton therapy treatment planning system

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proton therapy

treatment planning

pencil beam algorithm

Monte Carlo simulation

Abstract

Abstract

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Keywords

proton therapy

treatment planning

pencil beam algorithm

Monte Carlo simulation

Abstract

The increased interest in application of proton therapy for cancer treatment has propelled research and education in this filed worldwide. Computational tools such as treatment planning systems and Monte Carlo simulations are useful for both physics and clinical studies. Recently, a MATLAB-based Proton pencil beam Scanning treatment PLANning system, so-called PSPLAN, has been developed for research and education. The dose calculation engine used in PSPLAN is based on the pencil beam algorithm, for which the 3D dose distribution is computed from the product of the depth dose distribution and the lateral dose profile. The depth dose distribution in tissues is related to dose in water by the water-equivalent path length using voxel-by-voxel CT numbers and ratios of stopping power of tissues to that of water. The lateral dose profile calculation in PSPLAN also takes into account tissue inhomogeneity off the central axis. In homogenous media the lateral dose profile is assumed to have a Gaussian distribution while in heterogeneous media the lateral profile of dose deviates from the Gaussian distribution according to the water equivalent distance to the central beam axis. Verification of the pencil beam dose calculation method used in PSPLAN is verified with PHITS Monte Carlo simulation using actual tissue inhomogeneity obtained from patient CT images.

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© Copyright 2019 Morressier GmbH.
All rights reserved.