Serum IL-6,IL- 10 and substance p concentrations of patients administered distint anaesthetic techniques in breast cáncer surgery


Background : Breast cancer is one of the main causes of death between women. Even when surgery is supossed to be curative, patients can suffer from metastatic disease.A number of perioperative factors including anaesthetic technique might influence whether minimal residual micrometastases are eliminated o became full-blown metastasic disease.Apoptosis of tumoral cells is influenced by multiple factors, including inmune citoquine signalling. Many of these aspects can be modfified by anaesthesia.

Goal of Study:To determine whether serum levels of cytokines can be modified by regional/propofol anaesthesia.

Materials & Methods:20 women with diagnosis of breast cancer were randomized to receive either pectoral block with propofol anaesthesia (PEC) or general anesthesia with sevofluorane and opioids (GEN). Concentration of IL-6, IL-10 and substance P (SP) by using ELISA test were registered before induction, 1 h after surgery and 24h after surgery.

Results :Fig I, II and III show levels of IL-6, 10 and SP for both types of anesthesia. 


 
 
 

Discussion:  SP, and IL-6 stimulate tumor cell proliferation, migration and infiltration. IL-10 seems to inhibit cancer cell survival.
It has been proposed that local anesthetic can attenuate cytokine response in cancer surgery, however we didn´t find any association between type of anaesthesia and  levels of il-6, il-10 or SP (p>0.5),.


Conclusion: Maybe further studies should be necessary with a large number of patients to 

References: 1. Cancer surgery: how may anesthesia influence outcome? Cassinello, F; Prieto I;. Journal of clinical anesthesia 2015; 27 (3); 262-272

Serum IL-6,IL- 10 and substance P concentrations of patients administered distint anaesthetic techniques in breast cancer surgery