Materials and methods: Retrospective study in two major Jerusalem medical centers with IRB
approval. We identified women with PPH receiving ≥3PRBC units within 24hour period from blood
bank records. Our MTP, introduced in 2010, recommended 1:1 ratio of PRBC:FFP for PPH
management. Demographic, obstetric, blood management data were retrieved from the electronic
medical record. We compared estimated blood loss (EBL), PRBC, FFP administration and
hematological variables for 1:1 ratio of PRBC:FFP versus nonfixed
ratio, using descriptive
statistics.
Results: We identified 273 women (20042014).
EBL among women managed by 1:1 ratio was
2.26±0.74L versus 2.91±1.93L for nonfixed
ratio, p=0.04. PPH managed by 1:1 ratio required
median (IQR) 5 (46)
PRBC versus 6 (410)
PRBC units for nonfixed
ratio, p=0.013. PPH managed
with nonfixed ratio was associated with a higher likelihood receiving massive transfusion (≥8PRBC
units), Odds Ratio 2.88 95%CI 1.376.06.
Conclusion(s): PPH management using a 1:1 ratio PC:FFP strategy was associated with significantly lower EBL and PRBC requirements. The study findings support the recommendation of a 1:1 ratio of PRBC:FFP for PPH management.

Retrospective study to investigate the effect of fixed ratio management of packed red blood cell: fresh frozen plasma on blood management in postpartum hemorrhage