Cell adhesion molecule 1 (CADM1) was first identified as a tumor suppressor gene in a non-small cell lung cancer, and has been recognized as a favorable factor in malignant solid. On the other hand, the expression of  CADM1 is highly upregulated in adult T-cell leukemia/lymphoma tumor cells, leading to massive tumor formation. Therefore, it is assumed that a high expression of CADM1 in T-lymphoma cells might aggressively promote tumor development of malignant T cell lymphoma. Mycosis fungoides (MF) is an epidermotropic skin infiltration of atypical T lymphocytes, however, it remains unclear whether CADM1 affects the prognosis of MF. To clarify this issue, we analyzed the relationship between CADM1 expression and the prognosis of MF. Twenty-eight patients with MF were enrolled in this study. First, we confirmed CADM1 expression in tumor cell of MF by immunohistological technique.The overall survival rate was significantly lower in the CADM1 high-expression group compared with the low-expression group according to Kaplan-Meier survival analyses. These results demonstrated that CAMD1 expression is an independent prognostic factor for MF.

High expression of cell adhesion molecule 1 is a predictive unfavorable prognostic factor in patients with mycosis fungoides