BACKGROUND

In 2013, a study of vancomycin dosing practices in hemodialysis patients at Surrey Memorial Hospital identified opportunities for improvement.  Dosing recommendations were revised and education was provided to prescribers and renal pharmacists. A follow-up study was performed to assess the impact of these interventions. 


METHODS & OBJECTIVES

Retrospective chart review encompassing hemodialysis outpatients who were prescribed intravenous vancomycin and had at least one trough level done between 2014 and 2016 (inclusive).  We evaluated  the proportion of serum trough levels that were within the range of 10-20mg/L, and examined information on patient outcomes.


RESULTS & CONCLUSION

A greater proportion of serum trough vancomycin levels were found to be within the range of 10-20mg/L. These results reflect a mean loading dose of 20 mg/kg IV, and a mean maintenance dose of 10 mg/kg IV every hemodialysis run.  It is reasonable to continue with this dosing strategy going forward.

VANCO-HD II: Evaluation of Vancomycin Dosing Practices in Hemodialysis Outpatients at Surrey Memorial Hospital