THE ROLE OF VITAMIN D AND CALCIUM  IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

Koevska V¹, Nikolik-Dimitrova E¹, Mitrevska.B¹, Manoleva M¹, Gjerakaroska-Savevska C¹, Kalcovska-Ivanovska B¹, Gocevska M¹

¹Institute for Physical Medicine and Rehabilitation - Skopje, Macedonia

Introduction: In the treatment of postmenopausal osteoporosis (PMO),vitamin D and calcium has very important role to maintain and improve bone mineral density(BMD). Women with low vitamin D values have reduces absorption of calcium from the gastrointestinal tract.
Objective: To evaluate the role of vitamin D on BMD in postmenopausal osteoporosis.
Material and methods: 92 women with postmenopausal osteoporosis have regular physical activity, and used every day 800IU vitamin D and 800 mg Calcium. The level of serum vitamin D was measured by electrochemiluminiscence and BMD was determined by dual-energy x-ray absorptiometry, at baseline and after 12 months research.
Results: The average age of patients was 60.64 ± 6.7, education: primary 22 (23.9%), intermediate 45 (48.91%), and higher 25 (27.17%). Average BMI was statistically insignificant in start and after 12 months research (27.02 ± 63.9 kg /m2 v.s 27.07 ± 3.8 kg / m2, p = 0.7). The results have shown in this sample statistically significant value in mean vitamin D level at start and after 12 months (20,4± 9.03 v.s 30.93 ± 7.95, p<0.0001). Also, the results have shown statistically significant value in mean BMD of the lumbar spine and femoral neck, at start and after 12 months research (lumbar spine 0.71 ± 0.2g/sm2 v.s 0.77 ± 0.1g/sm2, p<0.0001 and neck of femur 0.8 ± 0.12 g/sm2 v.s 0.83 ± 0.1 g/sm2, p = 0.001).
Conclusion: vitamin D and calcium  significantly improves BMD in women with  PMO.