Analyses of prognostic factors in patients with candidemia: a retrospective cohort study

Objective: 
Patients with candidemia are associated with high mortality rates. The aim of this study was to analyse prognostic factors of clinical cases of patients culturally confirmed with candidemia over a period of 5 years (April 2009-March 2015) in Teikyo University Hospital. 
Methods:
A total of 237 adult patients was positively diagnosed with candidemia based on culture method. Primary isolation was done by serum bottle culture for 2 weeks. Identification of Candida spp. was carried out by CHROMagar and VITEK2 methods. Scoring approach of prognostic factors based on vital signs, blood analyses, and backgrounds of the patients, was developed. 
Results:  
The identification of the 237 candidemia cases revealed 51.48% Candida albicans, 22.36% Candida parapsilosis, 16.03% Candida glabrata, 6.75% Candida tropicalis, 1.69% Candida krusei, 1.69% Candida guilliermondii.  
Prognostic factors in patients with candidemia caused by C. albicans showed sensitivity of 72.1% and specificity of 75.4%.

Conclusion: 
Up to now, two scoring systems have been applied to evaluate the prognostic factors of patients in emergency, SOFA and APACHE II. However, there is no efficient and reliable scoring system to examine prognostic factors in patients with candidemia. Our propose system is a promising approach.