Avian aspergillosis produced by Aspergillus fumigatus is a global threat in terms of animal health and husbandry. Susceptibility to this fungal infection is host species-dependant, and poultry such as turkey poults, can show high morbidity and mortality rates. However, little is known regarding the features of avian immune response after inhalation of Aspergillus conidia and no information regarding inflammatory pathways has been so far described. The objective of this study was to improve the understanding of the interactions between A. fumigatus and local immune cells and the Th1-like immune response by comparing two avian models of acute aspergillosis.

Cellular and molecular insights on pro-inflammatory immune response regulation during acute Aspergillosis in chicken and turkey poults