Introduction
Oral cancer therapeutics have placed administration responsibility with the patient. Suboptimal medication adherence occurs in ~50% of patients across diseases, including cancer (1). An effective intervention is required to ensure survival benefits of therapeutics are realised (2).

Objectives
To detail development of an intervention to improve medication adherence and reduce errors for oral cancer therapeutics.

Methods
The initial intervention, REMIND, was developed utilising co-design with stakeholders: patients, haematologists, nurses and pharmacists. REMIND was pilot-tested with 10 patients.3 Results informed second iteration development: SAMSON.

Results
Results and pharmacist consultation identified further development should: enable use across chronic and for comorbid illnesses; improve medication interaction safety; maximise translation, distribution and consistency through online resources; improve doctor-patient adherence and side-effect reporting. Accordingly, the platform was expanded for multiple medications. Initial pharmacy consultation, including medication reconciliation and self-administration education, and final nurse consultation focused on relapse-prevention, have been added. Online nurse and pharmacist training and manuals were developed, and patient/clinician reporting facilities added. SAMSON is a 24-week comprehensive intervention that integrates pharmacy (week 1) and nurse tele-consultations (weeks 2, 3, 6, 10, 12), with ongoing APP support, through medication reminders, reinforcement, and side-effect advice. Weekly adherence and symptom reports provide patient feedback, guide nurse consultations and clinician review.

Conclusion
SAMSON targets cognitive, behavioural and affective aspects, creating long-term habits and providing ongoing support. Testing will assess feasibility, acceptability and efficacy in people prescribed oral cancer medication. SAMSON is expected to improve patient quality of life, reduce medication errors and related hospital admissions, optimising healthcare expenditure.

01 / DEVELOPMENT OF A COMPREHENSIVE INTERVENTION TO IMPROVE MEDICATION ADHERENCE AND REDUCE MEDICATION ERRORS IN PEOPLE TAKING ORAL CANCER THERAPEUTICS