What are the best outcome measures for MACRO trial - Defining best Management for Adults with Chronic RhinOsinusitis?

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Abstract

AIMS:
This study aimed to assess the proposed outcome measures to use in the MACRO trial and identify any redundant outcome measures.
METHODOLOGY:
Seventy patients with CRS underwent these proposed outcome measures:
•Objective: Peak Nasal Inspiratory Flow (PNIF), Peak Expiratory Flow, Saccharin test
•Subjective: Sniffin’ sticks test (TDI score), SNOT-22
Pearson’s correlations between SNOT-22 scores and outcome measurements were calculated. Interviews explored participants’ feedback.
RESULTS:

There was a significant negative correlation between SNOT-22 “Blockage” and PNIF. There was no significant correlation between SNOT-22 “Smell” rating and TDI scores; SNOT-22 “Runny” rating and Saccharin test. The interviews revealed the outcome measures were acceptable and valued by participants.

CONCLUSION:
The Sniffin’ Sticks test remains a valuable outcome measure. Although PNIF correlated with self-rating scores, it remains a simple cheap test to perform and valued by participants. The saccharin test was not valued by participants and has been removed from the trial measures.

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