Background and Goal of Study: comparing dexmedetomidine versus clonidine associted to bupivacaine in spinal anesthesia

Materials and Methods:double-blind prospective study including 60 patients ASA I or II, admitted for surgery of the femoral neck under spinal anesthesia. the anesthesiologist practice a slow injection, randomly, 10 mg hyperbaric bupivacaine associated with 15 mcg of clonidine (GC) or 3μg of dexmedetomidine (GD). neither the anesthesiologist nor the patient know the nature of the adjuvant. the same anesthetist notes the onset time of sensory block (prick-touch tst is negative in fracture site), the motor block (modified Bromage> 2), the occurrence of hypotension or bradycardia and use of analgesics during the 24 first hours(1g paracetamol if VAS> 3).

Results and Discussion :

 
	GC	GD	p
Age (years)	69,2±18,6	71,8±15,9	0,34
BMI(kg/m2)	21,6±2,3	22,1±1,8	0.42
sex-ratio	1,5	2,33	0,14
delay sensitif block (min)	7,6±2,4	5,2±1,3	0,041
delay motor bloc (min)	11,4±3,8	10,2±2,9	0,09
duration of motor block (min)	124,6±28,9	138±31,8	0,087
duration of sensitif block (min)	148,7±34,8	182,8±41,6	0,027
hypotension	16%	10%	0,54
bradycardia	6%	3%	0,66
Ephedrine (mg)	2,1±0,8	1,7±0,6	0,44
atropine (µg)	0	0	1
paracetamol(g)	1,2±0,4	0,7±0,4	0,039



Conclusion: dexmedetomidine in combination with bupivacaine is more effective than clonidine on the sensitive part of the spinal anesthesia


07 / Comparison of the efficacity and safety of dexmedetomidine versus clonidine in combation with bupivacaïne during spinal anesthesia for hip surgery