Background and Goal of Study. 
Obstructive sleep apnea syndrome (OSA) and small airway obstruction (SAO) are considered to be potential pathogenic ways of PE development since both lead to hypoxia and oxidative stress. At the same time PE itself can provoke early SAO mani-festations and aggravate the course of OSA. The aim of this study was to investigate pathogenic justification and efficacy of CPAP as a part of IC of pregnant women with severe early-onset PE.
Materials and Methods. 
The study was approved by the local ethics commission. All women signed writ-ten informed consent to the study. We conducted a monocentre prospective controlled study. All pregnant women with clinically defined severe early PE were divided into two groups: with OSA and without which was confirmed by somnography. Then patients were randomized to receive CPAP in addition to classic therapy, and classic therapy without CPAP. Thus were formed four groups: 1: the presence of OSA with CPAP (N=4); 2: the presence of OSA without CPAP (N=3); 3: non OSA with CPAP (N=11); 4: non OSA without CPAP (N=12). Settings CPAP: PEEP from 7 to 12 mm H2O, warmed humidified atmospheric air (FiO2 21%); every night from 10:00 p.m to 6:00 a.m. Mean arterial blood pressure (MAP), PaO2, PvO2, arteriovenous oxygen difference (a-vO2 diff), lactate, cerebral oxygenation (SrO2), outcomes such as gestation age, time of prolongation of pregnancy, neonatal outcomes were evaluated. The study was statistically validated using system "STATISTICA 10".
Results and Discussion.
In groups 1 and 3 there was an increase PaO2, PvO2, SrO2 and a decrease in a-vO2 diff and lactate at 6:00 a.m. in comparison with their level at 10:00 p.m.; there was a decrease in the need for antihypertensive therapy. In the group 4 initial value at 10:00 p.m. did not differ significantly from parameters in groups 1 and 3, but by 6:00 a.m. the dynamics of indicators have been identified. In group 4 there was an de-crease PaO2, PvO2, SrO2 and a inrease in a-vO2 diff and lactate at 6:00 a.m. in com-parison with their level at 10:00 p.m. The time from hospitalization to delivery in groups 1, 2, 3, 4 were 8, 2, 10, 6 days respectively. The average weight of newborns in all groups was not statistically different. All children born from mothers from groups 1, 3 did not required invasive lung ventilation (ILV), in groups 2, 4 - five children required ILV.
Conclusions.
CPAP may become a new effective additional method in the intensive care of severe early onset preeclampsia. It is planned to further study.


01 / Noninvasive respiratory support in the complex of intensive care (IC) management of severe early-onset preeclampsia (PE).