Background and Goal of Study:
Continuous infusion of rocuronium enables better and stable degree of relaxation, avoiding periods of unsufficient or too deep neuromuscular block, compared with bolus dosing. Due to the specificity of  knee-chest position in a  lumbar discectomy, many complications during anesthesia and surgery are possible so effective and balanced neuromuscular block is needed.
The hypothesis of this research was that continuous infusion of rocuronium during general anesthesia for a lumbar discectomy enables better quality of patient recovery as measured by questionnaire.

Materials and Methods:
80 patients (ASA I and II), aged between 18 and 65, for whom a lumbar discectomy was planned were randomly divided into two groups of 40 patients. In both groups general anesthesia was maintained with propofol and remifentanil with standard monitoring, BIS and TOF. In the control group rocuronium was administered in separate bolus doses with the TOF ratio of 5%, while in experimental group rocuronium was administered via continuous infusion so that the TOF ratio was 5%.
The quality of recovery after general anesthesia and surgery can be measured by Quality of recovery questionnaire (Qor-40). Qor-40 was assessed three times: before anesthesia, 24 hours after, and 30 days after anesthesia.
The results were analysed with t-test for independent samples using IBM SPSS Statistics version 24.

Results and Discussion:
The continuous rocuronium infusion group displayed better quality of recovery in terms of physical independence both in period 24 hours after anesthesia (p=0.035) and the 30 days after (p=0.011) (Fig 1). With regard to the other Qor-40 parameters (pain, patient support, emotional state and physical comfort) there were no statistically significant differences between the groups.

Conclusion(s):
Continuous infusion of rocuronium enables better quality of recovery than bolus doses in terms of physical independence both in early postoperative period as well as 30 days following lumbal discectomy. Further research on a larger sample and longer follow-up period coud additionally explain that influence.

08 / Comparison of the effect of continuous infusion and bolus doses of rocuronium during anesthesia for lumbal discectomy on the quality of patient recovery assessed with Qor-40 questionnaire