Background and Goal of Study: Diagnostic and prognostic value of the intravital parameters of purine
metabolism in acute cerebral pathology, including stroke, is studied in detail. Meanwhile, a study of postmortem biochemical processes may provide additional scientific information on the diagnostic value of the parameters of purine metabolism in neurointensive care. We investigated the postmortem parameters purine metabolism in stroke. 

Materials and Methods: In 50 adult ICU stroke patients, in the first 2 hours after the fact of biological death, the samples of cerebrospinal fluid (CSF) and venous blood on the were performed spectrophotometric determination of the concentration of adenine, guanine, hypoxanthine, xanthine, uric acid,malondialdehyde as a marker of free radical oxidation.

Results and Discussion:  Postmortem CSF levels of uric acid and malondialdehyde significantly higher in male patients than in female.

Uric acid in CSF significantly lower in the presence of intravital arterial hypertension, heart failure, pneumonia.
Pneumonia is also associated with a higher postmortem blood concentration of malondialdehyde, and multiple organ failure with a higher concentration of uric acid and malondialdehyde in CSF. The ratio of the CSF concentrations of uric acid / xanthine higher in ischemic, than in hemorrhagic stroke. The ratio of the concentrations of uric acid / xanthine, xanthine / hypoxanthine, uric acid / hypoxanthine was significantly lower in the presence of pneumonia in patients with stroke.

Conclusion(s): Oxypurines significantly associated not only with gender, arterial hypertension or stroke type, but also such lifethreatening and multiple organ failure.
Possibly, the mandatory inclusion of purines in the vital panel of monitored biochemical parameters will improve the results of neurointensive care.

02 / Stroke patterns of postmortem purines in blood and cerebrospinal fluid