Background and Goal of Study: In the conduct of general anesthesia cardiodepressant effects of anesthetics often have a critical effect on this contingent. We have considerable experience in conducting xenon anesthesia in ophthalmic operations. The aim of the study was to compare the course of anesthesia in patients older than 50 years with concomitant pathology under conditions of general anesthesia.
Materials and Methods: There was carried out a prospective comparative study during laryngeal mask combined anesthesia using xenon (group 1), n=27, sevoflurane (2), n=24 and isoflurane (3), n=23 in ophthalmic surgery. There were investigated: the indications of hemodynamics and oxygenation (the initial data, in 20, 40, 60 min), infusion volume and recovery time. Statistic study: descriptive analysis, U criterion Mann-Whitney.
Results and Discussion: An average age of patients in Xe group was 65 (8), Sev - 58 (9), Iso - 59 (9) years, accompanying pathology, duration and character of the operations in the groups were comparable.
The initial data between the groups differed insignificantly. In 20 minutes of anesthesia, TPR does not change in the group 1 with xenon and significantly decreases in groups 2 and 3 - by 27 and 48%, respectively (p <0.05). To stabilize hemodynamics in groups of halogenated anesthetics, a relatively larger amount of infusion was required than in the xenon group, which is unsafe in elderly patients with cardiac pathology. The recovery time of consciousness in the group 1 was 5(1) min, in the group 2 - 17(2) min, group 3 – 18(3) min (p <0.01).
Conclusions: Xenon is an anesthetic of choice for general anesthesia in elderly patients with concomitant pathology in ophthalmic surgery. The course of anesthesia is characterized by stable hemodynamics, the recovery from anesthesia is quick and comfortable.
Gupta А, Stierer Т, Zukerman R et al. Anesth. Analg. 2004; 98:632-641

04 / Vasoplegic effects of general anesthetics (xenon, sevoflurane and isoflurane) in elderly patients during ophthalmic surgery