Background: Intrauterine growth restriction (IUGR) is associated with adverse perinatal outcome. Affected foetuses display typical blood flow redistribution towards the brain (‘brain-sparing’). Accordingly, increased cerebral oxygen saturation has been observed in IUGR neonates within the first days of life.
Aim: Aim of our study was to assess behaviour of cerebral oxygenation during immediate neonatal transition in infants with and without IUGR.
Methods: This is a retrospective single-centre observational cohort study. Cerebral regional oxygen saturation (crSO2) was measured with near-infrared spectroscopy (NIRS) in neonates during the first 15 minutes after birth. Neonates with IUGR (IUGR group) were matched for gestational age (±1 week) and gender with neonates that were appropriate for gestational age (AGA). The AGA: IUGR matching ratio was 3:1. Arterial oxygen saturation (SpO2), heart rate (HR), crSO2, and cerebral fractional tissue oxygen extraction (cFTOE) were compared between the groups. 
Results: Between August 2010 and October 2017, 45 neonates with IUGR were identified and matched to 135 AGA neonates. Mean gestational age was 33.1 ± 3.0 in IUGR group and 33.5 ± 2.7 in AGA group. Mean birth weight was 1.559 ± 582g in IUGR group and 2.051 ± 679g in AGA group. There was a significant group difference in crSO2 beginning in minute 5 and continuing for the rest of the observation time with higher crSO2 values in the IUGR group (main effect group: p = .011; interaction time*group: p = .039). In cFTOE a significant difference could be observed in minute 5 to 9 and 11 to13 with lower rates of oxygen extraction in the IUGR group (main effect group: p = .025; interaction time*group: p = .463). Concerning SpO2 and HR, there was no significant difference between IUGR and AGA neonates. 
Conclusion: Neonates of IUGR group did show significantly increased crSO2 values and significantly decreased cFTOE values already during immediate neonatal transition.

01 - EFFECT OF INTRAUTERINE GROWTH RESTRICTION ON CEREBRAL OXYGENATION IN PRETERM AND TERM NEONATES DURING NEONATAL TRANSITION